Nanostructured materials and bioelectronic devices for the health and quality of life
Ilaria Bergenti, Eva Bystrenova, Marco Brucale, Massimiliano Cavallini, Alek Valentin Dediu, Chiara Dionigi, Mauro Murgia, Alberto Riminucci, Francesco Valle, Roberto Dragone, Antonella Curulli Primo, Giuseppina Padeletti, Daniela Zane, Daniela Ferro, Gabriella Di Carlo, Gabriel Maria Ingo, Saulius Kaciulis, Amedeo Palma, Mauro Satta, Maria Luisa Bondì, Maria Pia Casaletto, Francesco Michele Mingoia, Antonino Mazzaglia, Rosaria Plutino, Maria Angela Castriciano, Denis Gentili, Simone Bonetti, Marco Natali Assegnista di Ricerca, Santiago D. Qurioga, Saskia Karges, Ana Borrachero, Marianna Barbalinardo, Silvia Tortorella, Alessandra Campana, Chiara Botto, Erika Amore, Riccardo Delisi, Giuseppe Sortino, Gerardo Grasso, Rachel Cheng, Sabrina Salvati, Angelica Rapaccioli, Giulia Cocco, Valentina Benfenati Ricercatore, ISOF CNR, Fabio Biscarini, Professore ordinario - Università di Modena e Reggio Emilia, Stefano Casalini, Ricercatore - Università di Modena e Reggio Emilia, Assunta Pistone Assegnista di Ricerca ISOF CNR, Prof. Luigi Monsù Scolaro (UNIME), Andrea Romeo (UNIME), Prof. Mauro Tomassetti (UNI Sapienza), Prof. Fabrizio Monacelli (UNI Sapienza), Prof. Luigi Campanella (UNI Sapienza).
In this research field the ISMN expertise in nanotechnology is aimed at realizing nanostructured materials and devices useful for the health and quality of life.
Interdisciplinary and well-established expertise of ISMN were developed as part of several projects and nationally and internationally collaborations which qualified ISMN as a reference point for the promotion and development of activities aimed to creation of useful materials for the health and quality of life.
The main lines of research include the development of magnetic nanostructured scaffolds for regenerative medicine, nano-electronic devices implantable combined with biodegradable scaffolds to be used as a stimulus and monitoring of cellular activity, materials and bioelectronic devices based on field-effect transistor for the neuroregenerative medicine, study of mechanical stress under physiological conditions in biological systems and processes (Bologna).
Moreover, bio-electronic integrated (sensors/biosensors) and innovative devices are designed and developed for the detection and study of metabolic disruption by bioactive pollutants and for the monitoring and (tele)diagnostics in the environment and agri-food, biosensors to detect analytes in food and clinical and to prevent food fraud, nanocomposites based on calcium phosphate for the development of implants and patches for the healing of burns and wounds. Modeling studies surface/interface of material and biomolecules for a better understanding of interactions (Montelibretti and Sapienza).
The ISMN also makes use of skills in the realization of multifunctional supramolecular nano and mesoscopic structures of organic chromophores (porphyrins) and/or organic/ inorganic hybrid as biomimetic systems and agents in photodynamic therapy, in coordination complexes of platinum (II), nitrogen containing organic binders as target DNA and/or with antitumor activity. Nanomaterials based on cyclodextrins and for the delivery of anticancer and phototerapeutic drugs, diagnostic agents, and for genic material and to achieve stimuli-responsive devices able to study the cellular function.
Complement the activities of the LSR "Nanomaterials for health and quality of life," the realization and characterization physico-chemical and pharmaceutical-technological of lipid and polymeric nanoparicles for the delivery of drugs and genetic material, nanostructures for the delivery of nutraceuticals, the synthesis and exploration of anticancer properties and structural properties of nitrogen heterocycles polycondensated and surface characterization of nanostructured systems for drug delivery, of surfaces and interfaces of biomaterials and biomedical devices using spectroscopic techniques and X-ray diffraction (Palermo and Messina).