Francesco Michele Mingoia
tel. +39 091 6809368
/ fax +39 091 6809399
Sede Palermo - Via Ugo La Malfa, 153
Scientific responsible of research unit: Design, synthesis and evaluation of structural/biological properties of new nitrogen polycyclic heterocycles and development of new synthetic route with low environmental impact.
Main research interests
- Design, synthesis and evaluation of antitumor activity of new nitrogen heterocyclic structures
- Development of new efficient sequential synthetic methodologies catalyzed by Pd(II/0), Cu(I), Au(III), Fe(0)
- Optimization studies of lead compounds by structural modifications (SAR studies), including computational techniques
- Investigation of biological properties of new bioactive molecules
- Tailored synthesis of tunable pyrrole containing tricycle building blocks for optoelectronic applications
Francesco Mingoia graduated in Pharmacy at Palermo University (Italy) with full marks and honors.
After military service (133° AUC course), he was selected for a fellowship training (CNR/MISM), working at the Dep. “Farmacochimico”, University of Palermo
Subsequently, before the completion of his PhD thesis on Pharmaceutical Science, in December 1994 he was hired at the ICTPN-CNR as researcher.
He joined Prof. G. Poli research group (Pierre et Marie Curie University/CNRS, Paris (VI), France) collaborating on Pd catalyzed organic synthesis and development of new enantiopure ligands
Currently, he is as researcher at ISMN-CNR of Palermo division with research interests focused on organic synthesis applied in medicinal chemistry, nanomedicine and more recently in optoelectronic devices.
F. Mingoia, C. Di Sano, F. Di Blasi, M. Fazzari, A. Martorana, A.M. Almerico, A. Lauria, “Exploring the anticancer potential of pyrazolo[1,2-a]benzo[1,2,3,4]tetrazin-3-one derivatives. The influence on apoptosis induction, cell cycle and proliferation.” Eur. J. Med. Chem., 2013, 64, 345-356.
F. Mingoia, M. Vitale, D. Madec, G. Prestat, G. Poli: “Pseudo-Domino Palladium-Catalyzed Allylic Alkylation/Mizoroki-Heck Coupling Reaction: A Key sequence toward (±)-Podophyllotoxin.” Tetrahedron Letters, 2008, 49, 760-763
D. Madec, F. Mingoia, C. Macovei, G. Maitro, G. Giambastiani, G. Poli: “New Enantiopure Bis(thioether) and Bis(sulfoxide) Ligands from Benzothiophene.” Eur. J. Org. Chem., 2005, 552-557.
A.M. Almerico, F. Mingoia, P. Diana, P. Barraja, A. Lauria, A. Montalbano, G. Cirrincione, G. Dattolo: “1-Methyl-3H-Pyrazolo[1,2-a]benzo[1,2,3,4]tetrazin-3-ones. Design, Synthesis and Biological Activity of New Antitumor agents.” J. Med. Chem., 2005, 48, 2859-2866.
. A.M. Almerico, F. Mingoia, P. Diana, P Barraja, A. Montalbano, A. Lauria, R. Loddo, L. Sanna, D. Delpiano, M.G. Setzu, C. Musiu: “Pirrolo[1,2-f]phenantridines and Related Non-Rigid Analogues as Antiviral Agents.” Eur. J. Med. Chem., 2002, 37, 3-10.